Tuesday, March 17, 2015
Mechanism of action of Penicillin
Mechanism of action of Penicillin
Penicillin first binds with specific penicillin binding proteins (PBPs) that serves as drug receptor on bacteria. Then –
Ø Penicillin acts as a selective inhibitor of transpeptidase enzyme . So the transpeptidation (cross-linking) reaction is inhibited and peptidoglycine synthesis is blocked. As a result a fragile cell membrane is formed and thus cell membrane permeability increased . Now fluid goes inside the cell due to hypertonic internal osmotic pressure . The bacterial cell becomes swollen and ultimately the cell explodes and lysed.
.jpg) |
| penicillin |
Ø Penicillin actives an autolytic enzyme by removing or inactivating the inhibitor of autolytic enzyme in the cell wall – activated autolytic enzyme causes lysis of the bacterial cell wall in isotonic environment –Death of the bacteria .
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment